Drug Facts in Media

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and thereby the formation of strong drug-related memories, which can trigger relapse in individuals with substance use disorders (SUDs). The study, detailing these epigenetic mechanisms in the brain, uncovers a new molecular target for the development of novel SUD treatments.

A recent study found that people may perceive fewer negative effects of alcohol if they are also using cannabis at the same time.

A new study found that people with cannabis use disorder (CUD) had elevated dopamine levels in a brain region associated with psychosis.

Patients prescribed medicinal cannabis in Australia maintained improvements in overall health-related quality of life (HRQL), fatigue, and sleep disturbance across a one-year period, according to a new study. Anxiety, depression, insomnia, and pain also improved over time for those with corresponding health conditions.

A new study has analyzed and compared the fatty acids in the blood of individuals with schizophrenia, of those with cannabis use disorder and of those with both diagnoses, with the aim of shedding light on new biomarkers and improving the understanding of the biological relationship between the two disorders. The study also offers a powerful tool for identifying new biomarkers.

Marijuana is now legal in many places, but is it safe? Two new studies add to mounting evidence that people who use cannabis are more likely to suffer a heart attack than people who do not use the drug, even among younger and otherwise healthy adults. The findings are from a retrospective study of over 4.6 million people and a meta-analysis of 12 previously published studies.

A recently completed study found that certain terpenes in Cannabis sativa are effective at relieving post-surgical and fibromyalgia pain in preclinical models.

Researchers have developed a compound that relieves pain in mice but doesn't affect the brain, thereby avoiding mind-altering side effects and abuse potential. The custom-designed molecule, derived from cannabis, may provide an alternative to opioids for treating chronic pain.

Imagine a future where the grip of cocaine use disorder can be loosened, where cravings fade, and the risk of relapse diminishes. A new study brings this vision closer to reality. The research has identified a critical brain circuit that plays a pivotal role in regulating cocaine-seeking behavior.

A new study analyzes the disease burden and the risk factors for severity among people who suffer from a condition called cannabinoid hyperemesis syndrome. Researchers say the condition occurs in people who are long-term regular consumers of cannabis and causes nausea, uncontrollable vomiting and excruciating pain in a cyclical pattern that often leads to repeated trips to the hospital.

A new study has uncovered potential risks, including impaired fetal growth, associated with the use of both tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, as well as CBD, during pregnancy.

Researchers analyzed cannabis smoking practices to assess whether in-home smoking was associated with cannabis detection in children.

A new study found no changes in opioid outcomes among the general population with the states' passage of medical and recreational marijuana laws. However, the findings also show decreases in opioid outcomes after medical marijuana laws existed among people reporting cannabis use.

According to a new study, ketamine use has risen significantly since 2015. The results highlight the need for closer monitoring of recreational ketamine use.